Brain Centre

Research & Trials

Home › Research & Trials

Research

An Effectiveness and Safety Study of 'CONCERTA' (Methylphenidate Hydrochloride) in the Treatment of Adolescents With Attention Deficit Hyperactivity Disorder

13 Nov 2007
The purpose of this study is to evaluate the safety and effectiveness of CONCERTA (methylphenidate hydrochloride, a central nervous system (CNS) stimulant) versus placebo for the treatment of ... › More

Efficacy and Safety of Fingolimod in Patients With Relapsing-Remitting Multiple Sclerosis With Optional Extension Phase (TRANSFORMS)

4 Sep 2007
This study will assess safety, tolerability and efficacy of two doses of oral fingolimod versus interferon Beta-1a to reduce the frequency of relapses in patients with relapsing-remitting multiple ... › More

Study Evaluating the Safety, Immunogenicity and Tolerability of Meningococcal Group B Vaccine in Healthy Adults

10 Aug 2007
To determine the safety & immunogenicity of a potential vaccine against meningococcal B disease › More

PROMPT Clinical Trial for Migraine Prevention

23 Jul 2007
Various national and local guidelines demand revision of migraine prevention therapy after 4 to 6 months of treatment. However, there is no evidence from clinical studies to support the validity of ... › More

Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

17 Jun 2007
To determine long-term safety and efficacy of pregabalin in patients with partial seizures. › More

Study Evaluating the Safety, Tolerability, and Efficacy of Lecozotan SR in Outpatients With Alzheimer's Disease

3 Jun 2007
The purpose of the study is to determine the safety, tolerability, and efficacy of 3 doses of lecozotan in combination with a cholinesterase inhibitor in patients with mild to moderate Alzheimer's ... › More

Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke (SPARCL)

18 May 2007
To determine whether Lipitor reduces stroke, compared to placebo in patients who have had a previous stroke or transient ischemic attack. › More

Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma

25 Apr 2007
Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma.Drugs used in chemotherapy use different ... › More

Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy

5 Apr 2007
The purpose of this study is to see if male children with Duchenne muscular dystrophy (DMD) have changes in strength when given the drug Pentoxifylline as a rescue treatment. A total of 64 subjects ... › More

Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson's Disease.

30 Mar 2007
This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson's Disease-Questionnaire 8 (PDQ-8), in Parkinson's disease patients with no or ... › More

Trials

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

4 Sep 2007
This randomized phase III trial is studying standard-dose radiation therapy to see how well it works compared to reduced-dose craniospinal radiation therapy AND posterior fossa boost radiation ... › More

Cooperative Huntington's Observational Research Trial

24 Aug 2007
The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each ... › More

Prospective Research in Memory Clinics (PRIME), a Disease Registry for Current Management of Treatment and Outcome in Patients With Dementia (or Alzheimer's).

7 Aug 2007
The purpose of the PRIME (Prospective Research in Memory Clinics) Study is to examine the current management and outcomes of patients with dementia. Approximately 4500 subjects will be enrolled in ... › More

Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy

12 Jul 2007
The purpose of this trial is to determine if thymectomy combined with prednisone therapy is more beneficial in treating non-thymomatous myasthenia gravis than prednisone therapy alone. › More

Oral Dexamethasone for Treatment of Migraine

1 Jul 2007
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the ED [after successful treatment] prevents rebound headache. › More

Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents

8 Jun 2007
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents › More

A Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-583 in Subjects With Postherpetic Neuralgia (PHN)

31 May 2007
The purpose of the study is to assess the safety and ability of TAK-583 to relieve pain in subjects with PHN, compared with placebo. › More

Ancrod (Viprinex) for the Treatment of Acute, Ischemic Stroke

28 May 2007
The primary purpose of this study is to determine whether a brief intravenous infusion of ancrod started within 6 hours of stroke onset improves functional outcome at 3 months. › More

Effectiveness Of The Drug GSK189254 In Treating Patients With Narcolepsy

22 Apr 2007
The purpose of this study is to assess the effectiveness and safety of the drug GSK189254 in treating patients with narcolepsy. › More

Neurobiological Predictors of Huntington's Disease (PREDICT-HD)

30 Mar 2007
The purpose of this trial is to study early brain and behavioral changes in people who have the gene expansion for Huntington's disease, but are currently healthy and have no symptoms. › More

The support of the following commercial entities are greatfully acknowledged: